Designed brain-cancer peptide therapeutics and published at IEEE as a 10th grader
Working with YRI mentor Dr. Rajeshkhanna Bhuthkuri, Aly designed and evaluated four modular peptide constructs fusing the blood-brain barrier shuttle motif Angiopep-2 with the EGFR-targeting sequence GE11, aimed at the tumour-exclusive receptor variant EGFRvIII in glioblastoma. The pipeline used ESMFold for structure prediction, PatchDock for docking and BioPython for physicochemical profiling. Construct P3, a cyclized GE11 variant, was the only candidate rated High for blood-brain barrier permeability.
A 10th grader at Jumeirah College with strong CS and biology background and AI experience, but no peer-reviewed publication or drug design experience.
Published at a premier IEEE conference with a novel computational drug design pipeline for brain cancer therapeutics as a 10th grader.