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CASE STUDY · YRI FELLOW

From curious 10th grader to 1st place at a Princeton University science fair

Shaswat built a machine learning framework that predicts stem cell differentiation outcomes from RNA sequencing data. His pipeline processes gene expression data through feature extraction and ML classification to predict cell fate, helping researchers see which genes matter most in differentiation decisions. The research has implications for regenerative medicine and treating diseases like Parkinson's, diabetes and heart disease.

FIELDAI & Computational Biology
RESULT1st Place, Mercer Science & Engineering Fair at Princeton University
VENUEMercer Science & Engineering Fair, 2026
Shaswat Senthilkumar
Shaswat Senthilkumar, YRI Fellow1ST PLACE
BEFORE THE FELLOWSHIP

A 10th grader at West-Windsor Plainsboro HS South passionate about computational biology and machine learning, with no research or publication experience.

AFTER

1st place winner at the Mercer Science & Engineering Fair held at Princeton University with original ML research.

YRI helped me turn my interest in computational biology into a real research project. My mentor guided me through the entire process, from understanding RNA-seq data to building ML models. Winning 1st place at Mercer Science Fair was an incredible validation of our work.
SHASWAT SENTHILKUMAR
THE LEDGER
011st place at the Mercer Science & Engineering Fair held at Princeton University
02Built an ML pipeline predicting stem cell differentiation from RNA-seq data
03Identified the genes most important in determining cell fate decisions
04Contributed a predictive tool to regenerative medicine research
NEXT CASE STUDYAvyay G., 1st Place Science Fair and State Qualifier

Every case study starts with one application.

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